Pathology of BRCA1- and BRCA2-associated breast cancers: known and less known connections
نویسندگان
چکیده
منابع مشابه
Pathology of ovarian cancers in BRCA1 and BRCA2 carriers.
PURPOSE Germline mutations in the BRCA1 and BRCA2 genes confer increased susceptibility to ovarian cancer. There is evidence that tumors in carriers may exhibit a distinct distribution of pathological features, but previous studies on the pathology of such tumors have been small. Our aim was to evaluate the morphologies and immunophenotypes in a large cohort of patients with familial ovarian ca...
متن کاملWEARING BRASSIERE - A LESS WELL KNOWN FACTOR ASSOCIATED WITH BREAST CANCER IN WOMEN
Background & Aims: Considering the increasing prevalence of breast cancer, today, the main problem in the field of women's health is the control and prevention of breast cancer. One of the main areas in preventing this disease is controlling the risk factors associated with lifestyle. Wearing of brassiere is also a lifestyle-related habit that has sparked many debates today as a risk factor for...
متن کاملCancers associated with BRCA1 and BRCA2 mutations other than breast and ovarian.
BACKGROUND Previous studies have reported additional cancers associated with BRCA mutations; however, the type, magnitude of risk, and sex differences remain to be clarified. The purpose of this study was to evaluate the incidence of cancers other than breast and ovarian cancer in known mutation carriers. METHODS An institutional review board-approved study identified 1072 patients who had ge...
متن کاملCoronary heart disease risk factors: known and the less known.
ischaemic death is considered, it is the association of thrombosis with atherosclerosis that is paramount. It is important to understand the concepts of ‘plaque’ burden; the average number of plaques in the coronary arteries and the nature of plaques appear to determine the incidence of CHD. The level of inflammatory activity in the plaque makes it vulnerable and may lead to precipitation of th...
متن کاملRe: Multifactorial analysis of differences between sporadic breast cancers and cancers involving BRCA1 and BRCA2 mutations.
BACKGROUND We have previously demonstrated that breast cancers associated with inherited BRCA1 and BRCA2 gene mutations differ from each other in their histopathologic appearances and that each of these types differs from breast cancers in patients unselected for family history (i.e., sporadic cancers). We have now conducted a more detailed examination of cytologic and architectural features of...
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ژورنال
عنوان ژورنال: Annals of Oncology
سال: 2016
ISSN: 0923-7534
DOI: 10.1093/annonc/mdw363.53